Careers
Research Scientist, Toxicology (RST-095)
Ambit Biosciences is engaged in the discovery and development of small-molecule kinase inhibitors for the treatment of cancer. With more than 500 distinct kinases identified and over 30 kinase inhibitors in clinical trials or FDA approved, this important class of proteins is a rich area for therapeutic drug development. Ambit currently has two compounds in early stage clinical development and several active preclinical development projects. We are seeking a talented Toxicology Scientist to join our Toxicology team.
The Research Scientist Toxicology responsibilities will include, but are not limited to:
- Developing and executing non-clinical safety drug development plans for novel therapeutics with estimated cost, timing, and risk assessment/management
- Representing toxicology on research and development project teams and providing non-clinical safety assessment strategy
- Developing safety-related issue mitigation or resolution plans and coordinate execution of the experimental plan
- Serving as study director of non-GLP exploratory toxicology studies conducted at Ambit
- Interacting with contract research organizations to coordinate, design and monitor toxicology and safety pharmacology studies
- Reviewing CRO toxicology study reports and coordinate report finalization
- Coordinating cross-departmental activities necessary for the effective conduct of toxicology studies
- Communicating toxicology study findings, including relevance interpretation, to project teams and management
- Writing non-clinical sections of regulatory documents including IND and NDA submissions
- Authoring appropriate toxicology-related corporate documents and abstracts/manuscripts in peer reviewed journals
The successful candidate will have the following qualifications:
- PhD in toxicology or related field, or equivalent combination of education (MS, MD, DVM)
- DABT certification
- Three plus (3+) years experience working in toxicology/safety assessment, drug development, or contract research organization
- Experience participating on drug development teams and IND submissions
- Experience in designing, monitoring and interpreting non-clinical safety studies
- Excellent oral and written communication skills
- Competency in Microsoft Word, Excel, and Powerpoint software
- Familiarity with FDA and ICH guidance documents including GLP regulations
Interested candidates may apply directly online at www.ambitbio.com or email resumes to careers@ambitbio.com.
Please reference Job Code #RST-095.