KINOMEscan™ Technology
The Industry’s Most Comprehensive Kinase Profiling Service
KINOMEscan™ is an innovative, high-throughput method for screening small molecule compounds against large numbers of human kinases. By providing a fast, accurate, uniform and quantitative kinase profile that details how well each compound binds to both intended and unintended targets, KINOMEscan™ transforms the promiscuity of kinase inhibitors into a discovery advantage.
How it works
KINOMEscan™ is an active-site dependent competition binding assay in which human kinases of interest are fused to a proprietary tag. The amount of kinase bound to an immobilized, active-site directed ligand is measured in the presence and absence of the test compound.
New! Multiple Screening Options Available
scanMAX (402): Best choice for drug discovery and compound optimization
Definitive set of 402 kinases – the largest panel commercially available – covering all major kinase groups.
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scanEDGE (96): An economical approach to surveying the human kinome
Contains a set of 96 kinases distributed throughout the kinome.
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scanTK (117): The world's most complete collection of Tyrosine Kinases
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scanELECT: Ultimate flexibility for custom applications
An a-la-carte approach to exploring kinases of interest. Choose only the kinases you want.
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Binding Constant (Kd) Determination: Quantitative affinity measurement (11-point curve)
Can be determined for any kinase/compound combination using Ambit’s competition binding assay
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Library Screening and Annotation: Get more from your compound libraries
Rapidly and inexpensively screen hundreds or thousands of compounds against any Ambit kinase panel.
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The KINOMEscan™ Advantage
- Fast – Two-week turnaround
- Accurate – Compounds tested under uniform conditions
- Economical – Most screens delivered for under $10 per kinase per compound
- Consistent - Outstanding data reliability
- Confidential – All data blinded and protected