Priligy (dapoxetine) is the first drug developed specifically for the treatment of premature ejaculation in men. Such a deviation is not uncommon in our time. A lot of factors contribute to early ejaculation, which can be determined by several general points: natural abnormalities, improper lifestyle, and mental disorders.


The drug is used in sexopathology for the treatment of premature ejaculation in men.

This drug is recommended for patients who meet the following criteria:

  • insufficient control of the onset of ejaculation;
  • the latent time of intravaginal ejaculation is less than 2 minutes;
  • persistent or repeated ejaculation after minimal sexual stimulation before, during, and immediately after sexual penetration, which occurs earlier than the moment desired by the patient;
  • a pronounced state of stress or difficulties that arose in interpersonal relationships as a result of premature ejaculation.

The age at which this drug is safe and effective is from 18 to 64 years.

The drug is used only for the treatment of patients who have been diagnosed with premature ejaculation. It is not intended for men who want to prolong sexual intercourse by delaying the onset of ejaculation.

There is no data on the safety of the drug in men who have not been diagnosed with premature ejaculation.

Before starting treatment with this drug, men with other forms of sexual dysfunction (erectile dysfunction) should be examined by a doctor.

The mechanism of action of dapoxetine in premature ejaculation is associated with a delay in neuronal reuptake of serotonin and further enhancement of the action of neurotransmitters on presynaptic and postsynaptic receptors.


Priligy is not used if the patient has an increased sensitivity (allergy) to one of the components that are part of the drug.

Other contraindications include:

  • heart failure;
  • violation of conduction of the heart (AV block, weak sinus syndrome);
  • cardiac ischemia;
  • defects of heart valves;
  • hepatic and renal failure in a moderate to a severe degree;
  • syncope in history;
  • mental disorders (mania, severe depression) in history;
  • age under 18 years.

Pregnancy and lactation

This drug is not used in the treatment of females.

Dosage and administration

The drug is taken orally (swallowed whole, washed down with a full glass in 200 ml of water).

The time of admission is independent of food intake.

The recommended initial dosage is 30 mg, which is taken 1-3 hours before sexual intercourse.

Treatment should not be started with a dosage of 60 mg. Dosage can be increased only if there was no effect of taking the drug at a dose of 30 mg, and also if the patient did not experience adverse reactions of moderate or severe severity after taking the minimum dosage or symptoms that could indicate a possible development of loss of consciousness. If such symptoms are not observed and the effect of taking the minimum dosage is insufficient, then the dosage can be increased to 60 mg per 1 dose (per day).

Keep in mind that the frequency and strength of side effects increase when taking a dosage of dapoxetine 60 mg.

Do not exceed the maximum allowable dosage and frequency of taking pills – 1 time per day (24 hours).

If intercourse is not expected on this day, then you do not need to take a pill.

The clinical need for continued treatment with this drug is evaluated by the attending physician after the first four weeks of treatment, or at least after 6 (six) doses taken.

Further consultations should be carried out at least once every six months.

Patients with mild severity of renal and hepatic insufficiency do not require adjustment.

The drug is not intended for elderly patients aged 65 years and older.


An overdose of dapoxetine has not been fixed at the moment.

Theoretically, overdosing can cause signs of poisoning – nausea, vomiting, tachycardia, tremors, agitation, and fainting.

Recommended treatment includes gastric lavage, taking enterosorbents, symptomatic treatment.

Dialysis, hemodialysis, forced diuresis, hemoperfusion, or blood transfusion are ineffective.

There is no known specific antidote to date.

Side effects

In some cases, Priligy can cause the following side effects:

  • depressive states, euphoria, mood swings, nervousness, anxiety, sleep disorders, bruxism, decreased sex drive, anorgasmia;
  • dizziness, headache, drowsiness, tremor, violation of taste sensations, sedation, sudden drowsiness;
  • mydriasis, eye pain, visual impairment;
  • vertigo, ringing in the ears;
  • skin hyperemia, hot flashes, hypotension, tachycardia, orthostatic hypertension, increased blood pressure;
  • nasal congestion, dry mouth, nausea, vomiting, diarrhea, constipation, dyspepsia, flatulence, urge to defecate;
  • skin rash, hyperhidrosis, itching, cold sweat;
  • erectile dysfunction, ejaculation disorders, paresthesia in the male genitalia;
  • allergy;
  • weakness, increased fatigue, fever, anxiety, a feeling of intoxication, withdrawal syndrome.

If you get any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Compatibility with alcohol

In the case of a reasonable approach to alcohol consumption, Priligy and alcohol are a valid combination but not recommended by the manufacturer. It is important to remember that large doses of alcohol in combination with this drug can have negative consequences. Dapoxetine is a drug that acts on the brain (a selective serotonin reuptake inhibitor). This increases the risk of side effects dramatically.

Interaction with other drugs

Avoid taking Priligy with the following medications:

  • herbal medicines with serotonergic effects;
  • MAO inhibitors;
  • drugs metabolized by CYP 2D6;
  • drugs metabolized by CYP 3A4;
  • drugs metabolized by CYP 2C9;
  • drugs metabolized by CYP 2C19;
  • thioridazine;
  • tamsulosin;
  • PDE-5 Inhibitors;
  • medications for the central nervous system;
  • CYP 3A4 inhibitors;
  • medium-acting CYP 3A4 inhibitors (erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem);
  • potent CYP 2D6 inhibitors;
  • warfarin and medicines that affect blood coagulation and/or platelet function.

If you are currently taking any of the medicines given above, you must consult a doctor before using dapoxetine pills.


Priligy has a slight or moderate effect on the ability to drive vehicles or other mechanisms. The medicine caused dizziness, impaired attention, fainting, blurred vision, and drowsiness in some individuals. Therefore, patients should be warned about the need to avoid traumatic situations, including driving and servicing machinery.

Data regarding the efficacy and safety of the drug for more than 24 weeks are limited. The clinical need for continued treatment and the risk-benefit ratio of treatment should be reviewed at least every six months.

The efficacy and safety of the drug have not been established for patients over the age of 65.

Caution should be exercised when taking the drug if you have the impaired renal function of a mild or moderate degree. It is not recommended to take the drug if you have severely impaired renal function.

Patients with moderate or severe liver dysfunction should not use the drug.