Cialis
Cialis 20 mg is an innovative drug aimed at eliminating problems associated with impaired male potency. A generic option has an action similar to the branded drug – Cialis, which is released by an American pharmaceutical company. Generics are produced in India. In both drugs, tadalafil acts as the active substance, which for many years has been successfully used for the prevention and treatment of erectile dysfunction.
Operating principle
As the main active component, a reversible selective inhibitor – tadalafil is used. Its action is aimed at reducing the tone of the smooth muscles of the arteries at the time of sexual excitement. Due to this, the blood flow to the penis increases, which contributes to the appearance of a stable and persistent erection.
One of the main advantages is that an erection is achieved in a natural way. Tadalafil promotes the production of nitric oxide in the body, which has a relaxing effect on the smooth muscles of the cavernous bodies. In this case, an involuntary erection is completely excluded, since it is the result of natural excitement.
Drug effect
After taking the pill, the duration of normal and persistent erection can reach up to 36 hours. During this period of time, you can perform a number of sexual intercourse, while maintaining a stable erection.
Cialis dosage
Manufacturers produce tablets of different dosages. One tablet of this product contains 20 mg of the active substance. This is the optimal dosage of the pathogen required by the male body. This drug is taken 20 to 30 min before sexual intercourse, which will result in an enchanting orgasm.
Side effect
Generic Cialis, in very rare cases, can cause:
- dizziness;
- headache;
- muscle pain;
- lower back pain;
- allergies;
- runny nose;
- face flushing;
- impaired coordination of movements.
But even if a side effect is manifested, then it is expressed very weakly and almost imperceptibly. In addition, it disappears on its own after some time. With Generic Cialis, 20 mg is a modern drug aimed at eliminating problems associated with impaired potency in men. Generic Cialis 20 mg has an action similar to the branded drug.
Contraindications
Cialis instructions prohibit taking the drug in the case of:
- individual intolerance to the drug;
- angina pectoris;
- heart, kidney and liver failure;
- penile deformities;
- nitrate treatment.
You can not combine Cialis tablets with similar drugs and doxazosin. It is also not recommended to take them to persons under the age of 18 years old.
It is not recommended to take Cialis before classes that require concentration, especially before driving.
Drug interaction
The effect of other drugs on tadalafil
Tadalafil is mainly metabolized by the enzyme CYP3A4. Selective CYP3A4 inhibitor ketoconazole at a dose of 400 mg increases the AUC of tadalafil in a single dose by 312%, Cmax – by 22%.
Ritonavir (200 mg), an inhibitor of CYP3A4, 2C9, 2C19 and 2D6, increases the AUC of tadalafil in a single dose by 524% without changing Cmax. Although specific interactions have not been studied, it can be assumed that other HIV protease inhibitors, such as saquinavir, as well as CYP3A4 inhibitors such as erythromycin and itraconazole, increase tadalafil activity. The selective inducer rifampin CYP3A4 (rifampicin, 600 mg), reduces the single-dose of tadalafil AUC by 88% and Cmax by 46%, relative to the AUC and Cmax values for tadalafil only.
Advantages
The advantages of Cialis include:
- ability to normalize sex life;
- safety proven in clinical trials;
- almost instant result;
- long action;
- naturalness;
- lack of causeless excitement;
- does not affect the cardiovascular system performance;
- combined with alcohol and food;
- perfectly tolerated by the body;
- not addictive;
- can be used for diabetes;
- relieves symptoms;
- does not change the chemical composition of sperm;
- does not affect childbirth and the health of the unborn child;
- practically does not show side effects;
- almost no contraindications.